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engeneOS a pioneer in biomolecular engineering

Firm's nanocrystal antennas may control biomolecules

February 28, 2002

engeneOS was formed in late 2000 to exploit the opportunity at the intersection of the biological, physical, and information sciences. By integrating knowledge from genomics research with technologies from the physical and information sciences, the company is pioneering the commercialization of Biomolecular Engineering.

The Boston-based company designs and manipulates proteins to build everything from nano-atennas to programmable biomolecular devices. Nano-antennas uniquely marry inorganic nano-crystals with organic materials (engineered bio-molecules), creating antennas for RF signals to control molecules in living cells or even control the delivery of drugs to patients. The process uses biomolecules with radio frequency energy, and switches them from one state to another. The authors of an article entitled "Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna," that was recently published in Nature magazine, included three key members of the engeneOS team.

"We were interested in creating a new method to electronically and remotely control individual biomolecules. These directions may be useful in interfacing the molecular scale machinery of biology to the infrastructure of digital electronics," said Dr. Jacobson, Ph.D. a founder of engeneOS and a member of the Company's Scientific Advisory Board (SAB) and Board of Directors. A second author, Dr. John Schwartz, Ph.D. is also a founder and a Principal Scientist at engeneOS. The third author, Dr. Shuguang Zhang, Ph.D., is a member of the Company's SAB.

engeneOS' technology platform starts with the "source code" of Nature's operating system, embodied in the genomic sequences of various organisms. The company is combining this information with modern molecular biology techniques, engineering and design principles to develop Engineered Genomic Operating Systems. These systems will consist of component device modules supported by modeling and design tools. engeneOS expects to build a library of proprietary modular components,

The Company has an interdisciplinary scientific advisory board including Joseph Jacobson, Ph.D., of the Massachusetts Institute of Technology's Media Lab, Eric Lander, Ph.D., of the Whitehead Institute Center for Genome Research at MIT, Daniel I.C. Wang, Ph.D., of the Department of Chemical Engineering at MIT, George Church, Ph.D., of the Department of Genetics at Harvard Medical School, and Stephen Benkovic, Ph.D. of the Department of Chemistry at Pennsylvania State University. For additional information, see www.engeneos.com.






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